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Hematologów i Transfuzjologów

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Acta Haematologica Polonica, 2012, 43, 4

Patrycja Rzepka · Aleksandra Majewska · Lech Sedlak · Tomasz Oleksy · Grzegorz Helbig · Sławomira Kyrcz-Krzemień

An extremely rare lineage switch from T -cell lymphoblastic lymphoma into B-cell acute lymphoblastic leukemia at relapse.

Niezwykle rzadki przypadek konwersji T-komórkowego chłoniaka limfoblastycznego w ostrą białaczkę limfoblastyczną w nawrocie

T-komórkowy chłoniak limfoblastycznyB-komórkowa białaczka limfoblastycznakonwersja
T-cell lymphoblastic lymphoma; B-cell lymphoblastic leukemia; lineage switch
pełna treść »
STRESZCZENIE: Lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) is a neoplasm
of precursor B or T-cells. These neoplastic cells may infiltrate
bone marrow and peripheral blood (acute lymphoblastic leukemia) or
their presence is confined to nodal or extranodal sites with only minimal
evidence of blood and bone marrow involvement (lymphoblastic lymphoma).
Herein, we report a male patient with infrequent neurological
manifestation of T-LBL who failed autologous hematopoietic stem cell
transplantation (AHSCT). A lineage switch from T-cell lymphoblastic
lymphoma into B-cell acute lymphoblastic leukemia was observed at
relapse and this phenomenon has not been described so far. Our case
demonstrates difficulties which may occur in diagnosis and treatment
of LBL/ALL. It should be underlined that neurological deficits resulting
from spinal cord compression may be the first symptom of lymphoma.
A switch within the lymphoblastic line may occur but it is an extremely
rare finding. Its pathogenesis remains unclear, therefore further studies
are highly required.