Polskie Towarzystwo
Hematologów i Transfuzjologów

czcionka: [+] powiększ | [-] pomniejsz

Acta Haematologica Polonica, 2013, 44, 1

Zofia Szemraj-Rogucka · Janusz Szemraj · Olga Grzybowska-Izydorczyk · Tadeusz Robak · Krzysztof Jamroziak

CD38 gene polymorphisms and genetic predisposition to multiple myeloma

Polimorfizm genu CD38 a predyspozycja genetyczna do szpiczaka mnogiego

SłOWA KLUCZOWE:
szpiczak plazmocytowyCD38polimorfizmpredyspozycja genetyczna
KEY WORDS:
Multiple myelomaCD38PolymorphismGenetic susceptibility
pełna treść »
STRESZCZENIE: -
SUMMARY: Single nucleotide polymorphisms (SNPs) of adhesion and signaling genes may influence
the etiopathogenesis of multiple myeloma (MM). CD38 molecule and its ligand CD31 are
expressed and interact in malignant plasma cells and MM microenvironment. In this
study we evaluated allele frequencies and distribution of two potentially functional CD38
SNPs, intronic rs6449182 (184C>G) and missense rs1800561 (418C>T, Arg140Trp) in 175
Caucasian patients with MM and 207 healthy blood donors. The carriers of variant
G allele of the rs6449182 SNPs were found to have significantly elevated risk of MM as
compared to non-carriers; odds ratio = 5.69 (95% confidence interval = 3.7–8.7), p < 0.0001.
In contrast, rs1800561 SNP minor T allele was detected at very low and comparable
frequencies in patients and controls groups. In conclusion, our data suggest that inherited
genetic variation in CD38 gene may impact on the risk of MM development.

pełna treść:

pobierzpobierz pełną treść publikacji (PDF 216kb)

Pobierz program Adobe Reader®Do otwarcia plików PDF niezbedny jest darmowy program Adobe Reader® Jeśli nie masz tego programu pobierz go tutaj