Polskie Towarzystwo
Hematologów i Transfuzjologów

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Acta Haematologica Polonica, 2010, 41, 4

BEATA KULIK-RECHBERGER · ELŻBIETA SZPONAR · ARTUR KOŚCIESZA · WANDA FURMAGA-JABŁOŃSKA

Rozpuszczalny receptor transferyny jako wskaźnik zasobów żelaza u noworodków i niemowląt urodzonych o czasie i przedwcześnie

Soluble transferrin receptor as a marker of iron stores in fullterm and preterm newborns and infants

SłOWA KLUCZOWE:
Rozpuszczalny receptor transferynyZasoby żelazaWcześniakNoworodek donoszony
KEY WORDS:
Soluble transferrin receptorIron storesPretermFullterm newborn
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STRESZCZENIE: Soluble transferrin receptor (sTfR) is a form of tissue transferrin receptor circulating in blood, which is responsible for donation of iron into the cells. The aim of the study was evaluation of sTfR serum concentration in preterm and term newborns regarding classic markers of iron stores like iron and ferritine concentrations and blood counts. The study group was composed of 117 fullterm and preterm newborns and infants between 1–20 weeks of chronological age. The children were divided into three groups: preterms with a gestational age of 24–31 wk (n=32), preterms with a gestational age of 32–37 wk (n=42) and fullterm newborns (n=43). Our results revealed that fullterm newborns had higher ferritin but lower sTfR concentration than preterms (p<0.02), especially when born before 32 weeks of gestation. The latter had also significantly higher reticulocyte count. The sTfR concentration correlated negatively with gestational age, birth weight, iron and ferritine serum concentrations, and correlated positively with reticulocyte count. On the basis of our investigation it can be concluded that serum sTfR concentration may reflect iron requirement during intensive erythropoesis as well as its intensity.
SUMMARY: Soluble transferrin receptor (sTfR) is a form of tissue transferrin receptor circulating in blood, which is responsible for donation of iron into the cells. The aim of the study was evaluation of sTfR serum concentration in preterm and term newborns regarding classic markers of iron stores like iron and ferritine concentrations and blood counts. The study group was composed of 117 fullterm and preterm newborns and infants between 1–20 weeks of chronological age. The children were divided into three groups: preterms with a gestational age of 24–31 wk (n=32), preterms with a gestational age of 32–37 wk (n=42) and fullterm newborns (n=43). Our results revealed that fullterm newborns had higher ferritin but lower sTfR concentration than preterms (p<0.02), especially when born before 32 weeks of gestation. The latter had also significantly higher reticulocyte count. The sTfR concentration correlated negatively with gestational age, birth weight, iron and ferritine serum concentrations, and correlated positively with reticulocyte count. On the basis of our investigation it can be concluded that serum sTfR concentration may reflect iron requirement during intensive erythropoesis as well as its intensity.

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